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KMID : 0357920050390060418
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Korean Journal of Pathology
2005 Volume.39 No. 6 p.418 ~ p.423
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The Expression of Matrix Metalloproteinase-9 and Tumor Angiogenesis in Human Osteosarcoma
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Yoo Jin-Young
Jung Ji-Han
Kang Seok-Jin
Choi Hyun-Joo
Lee An-Hi
Seo Eun-Joo
Shim Sang-In
Kang Chang-Suk
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Abstract
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Background: Matrix metalloproteinase-9 (MMP-9) is a matrix-degrading enzyme that’s believed to play a crucial role not only for tumor invasion and metastasis, but also for a variety of stromal reactions, including neovascularization. The aim of this study was to investigate the expression of MMP-9 and to compare its expression with the angiogenesis activity in human osteosarcoma.
Methods: Archival tumor tissue samples from 20 patients with osteosarcoma were analyzed by performing immunohistochemistry for the expression of MMP-9 and CD34. The vascularity was measured as the average microvascular density (MVD) of the CD34-positive vessels. The clinical information was obtained through searching the computerized retrospective database from the tumor registry.
Results: MMP-9 was expressed in 90% (18/20) of the tumors we examined. The MVD ranged from 10.5 to 179.7 with a mean of 64.9. There was no significant correlation between the MMP-9 expression and the MVD (p=.613). The MMP-9 expression was not associated with any of the clinicopathologic variables, whereas the MVD showed an increasing tendency according to the metastasis status (p=.073).
Conclusions: We demonstrated that MMP-9 activation is likely to occur in human osteosarcoma. However, there was no direct involvement of MMP-9 with tumor angiogenesis. It is noteworthy that MVD may aid physicians to predict the presence of distant metastasis in osteosarcoma patients.
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KEYWORD
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MMP-9, Angiogenesis, Osteosarcoma
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